Saturday, December 15, 2012

More Trial Results



We have written before about the benefit of the Beta Glucans in TrueGlo to the immune system. They work by improving macrophage function while simultaneously decreasing some of the negative acute phase proteins the immune system generates.
In this document we will review some of the other trial work we did this fall that demonstrates why active macrophages in high numbers are very important to your animals. In the next entry we are going to review some recent research that was done on the interaction between Beta Glucans and mycotoxins.
In the work we did this fall we attempted to simulate a show pig being hauled to a show where they are exposed to disease and brought home. In this case the disease we challenged them with was Actinobacillus pleuropneumoniae (App.) One group was fed our TrueGlo product and treated with Draxxin, another group was not fed TrueGlo but was treated with Draxxin . The third group was untreated  before or after challenge.  We measured both mortality and the percentage of the lung diseased at the conclusion of the trial.
We chose Draxxin as the antibiotic for two reasons. First, show pig exhibitors commonly use Draxxin. Second, it is in a class of antibiotics known as macrolides and they concentrate in the macrophage and use these cells to get access to the disease causing bacteria. What we thought going into the trial was that because Beta Glucans increase both the number and the activity of macrophages we would get a better response from these antibiotics when animals were receiving TrueGlo. We were right! 



Feeding TrueGlo improved the performance of Draxxin in this trial. Pigs supplemented with TrueGlo had 3 times better chance of surviving the challenge and had about 30% less damage to their lungs than pigs that were treated with Draxxin alone.  
Using antibiotics responsibly is in the livestock industry’s best interest. We need to use them judiciously and when our animals get sick we need to make sure we are getting the most we can out of the antibiotics we have available. In this regulatory environment, we are not getting any new antibiotics anytime soon so we need the ones we have to work for a long time. Feeding a supplement like TrueGlo is one way to reduce the use of antibiotics and make sure they have the very best chance of working when you do. 

Visit www.goinshowin.com, drop us an email, or give us a call. We would love to help and answer any questions you have. 












Tuesday, December 4, 2012

Fall Trial Work MOS



The secret to how TrueGlo works is in the combination of ingredients and is an example of the whole being greater than the sum of its parts. That said to build understanding we are explaining each component individually.  TrueGlo contains a number of beneficial metabolites that improve livestock health and performance naturally. These are derived from bacterial, yeast and plant sources, including live bacterial probiotics, Octacosanol, Beta Glucans, MOS, Mannose, and Glucosamine.

Last month we wrote about octacosanol and the positive effects it has on muscle metabolism and how it helps your animals drive longer and builds the “right kind” of muscle for your show stock. In the past, we have written about Beta Glucans and their effect on stimulating the immune system and improving the immune response. In our next post we will go back to Beta Glucans and talk about a few properties they have and how they bind mycotoxins and how important that is this year.  Today we are going to discuss MOS and mannose and their positive effects.    

MOS stands for Mannan Oligosaccharide it is a complex carbohydrate and is composed of mannose sugars connected in long branched chains so it looks like a cactus. MOS has a host of benefits for livestock and that is why it is an important part of TrueGlo. 

First, since animals do not have the ability to break down MOS so it passes intact through the gastrointestinal tract. The cool thing is that once it gets to the lower intestinal tract it serves as a food source for beneficial bacteria. Good bugs like Lactobacillus, Bifidobacterium, and Enterococcus use the MOS as food.  As they grow, they are better able to compete with bad bugs. This is called competitive exclusion. What that means for you is a better appetite and performance over the long term.

Second, bad bugs like E. coli and Salmonella are highly attracted to both mannose and MOS and actively attach to it. Once they are attached to MOS they cannot attach to the animal’s intestine and cause disease.  Pathogenic bacteria are literally passed out of the animal harmlessly attached to MOS. The effect of MOS at controlling things like E. coli and Salmonella is well documented in scientific literature.  Eliminating these nasty pathogens before they can cause disease means your animal can achieve its genetic potential.

This fall one of the trials we did was a challenge study where pigs with ileitis were assigned to three treatment groups. One group of pigs received no treatment, the second group received tylosin in the water and the third group received nothing except TrueGlo as a top dress. We tracked their scours scores on a three-point scale over a period of 14 days. A score of 1 is a normal formed stool and a score of three is a watery stool.  The results of the trial were that TrueGlo was as effective as tylosin at returning stools to normal. TrueGlo also tended to be slightly more effective than the antibiotic treatment when it comes to average daily gain and feed efficiency. There are two graphs of the trial results below.  

The first represents the average scour score for pigs by treatment group. Scour scores are a three point scale. A score of 1 means normal formed stool, 2 indicates an unformed or cow pie consistency and 3 is watery.   TrueGlo and Tylosin performed very similarly in severity and duration of scours.  The second chart is feed efficiency and growth rate and both TrueGlo and Tylosin outperformed no treatment with TrueGlo having a  slight numerical advantage over the antibiotic treatment. 


The third major benefit of MOS is an improved immune system. In work conducted at the University of Illinois they demonstrated that animals fed MOS and challenged with the PRRS virus had enhanced immune function and response to the disease without the kind of over reaction of the immune system that kills performance. A meta-analysis of studies on cattle show cattle fed MOS in the receiving period have rates of sickness  over 60% lower than cattle that are not fed MOS. Because of the unique stress and disease challenges that we subject show stock to it is important to feed a product like TrueGlo throughout the feeding period. Doing so helps protect the investment you’ve made in your project animals.

All sources of MOS are not created equal and TrueGlo has multiple sources of MOS that we quantify and test for purity and effectiveness. We do the science so you don’t have to. Our goal is to bring you innovative solutions that get you in the champion drive.  

You can find more about TrueGlo here www.goinshowin.com 

Sunday, November 25, 2012

What You Need to Have in Your Medicine Cabinet for Your Show Pig Project




One of the frequent things I get asked is what medications show pig families should have on hand. Administering medications to food animals is serious business and proper care should be taken to use the right product at the right time the right way. Make sure that people that are doing so are properly trained and keep appropriate records.

The goal here is not to replace the advice you get from your veterinarian. Some of the drugs that we will discuss are prescription and some you will use extra label so your relationship with your local veterinarian is critical.This is meant to provide some baseline information on a few common medications and how they are used. 

Before we get to the medications let’s talk equipment. Having the right gear is mission critical and will save you time, money, and frustration.  

Syringes:
I really like the Ardes syringes for giving individual animal treatments. The fit in your hand and are lots easier than trying to use a disposable and are a lot cheaper than a multi-dose pistol grip. If you can’t find them at a local clinic or store QC Supply has them for about $6. You will want a 10 cc and a 20 cc. The 20 cc is actually easier to handle if you have small hands but the 10cc is more accurate to measure smaller doses. 

Needles:
I like these D3 detectible needles from Ideal. They cost a few pennies more but their construction makes them much less likely to break and if they do they are detectible so we can find a retrieve them.
As far as the size needles you need use this chart from the PQA program as a guide. 


Thermometer:
You really should have one of these on hand. The cheap digital ones you can get at your local pharmacy work just fine and don’t break like glass ones. The normal temperature for a pig is 102.5 but can vary a bit. Younger pigs will have a slightly higher normal body temp.

Sorting Panel
If you are going to give pigs injections, you really need one of these. 

Medications:  For each of the medications we will discuss what it isused for, withdrawal, and dosage. Your veterinarian knows what works best in your area so their advice is mission critical. 

Wormers: The normal recommendation is to de worm your show pigs once a month.

Safeguard. You need to feed Safegard for three to 12 days in a row . Safeguard comes in many forms but the easiest for show pigs might be the Safeguard EZ Scoop that is meant for sows. The scoop that comes in the 10 pound bucket treats 400 pounds so use ¼ scoop for a 100 pound pig and give that same amount three days in a row.  There is no withdrawal. 

Ivermectin  is not a great wormer as far as being a broad spectrum. It kills worms that have round bodies but it is not effective on the ones with flat bodies like hookworms.  But it does have the advantage of killing lice and mange.  Lots of people use it when they have pigs in isolation and after coming home from a show  for that purpose. The dosage is 1 cc per 75 pounds and the withdrawal is 18 days. 

Anti-Inflammatory Meds:

Banamine S  is a prescription non steroidal anti inflammatory and is labeled to relieve fever during respiratory disease. The dosage is 2 cc per hundred pounds IM  and the withdrawal is 12 days. In addition to relieving fever this product also relieves pain and inflammation so there are a number of extra label uses you will want to discuss with your veterinarian. 

Dexamethasone  is a prescription steroidal anti inflammatory.  It is labeled for use in cattle and horses so it is always extra label use when you administer it to pigs. As such your veterinarian will establish both the withdrawal time and the dosage. When we label it for our clients we label it for 1 cc / 40# IM or SubQ  and use 8 days for a withdrawal time. 

Vitamins / Minerals / Other 

B Complex Is an over the counter product but there are some formulations that are prescription. It can be used to treat and prevent the symptoms of Vitamin B deficiency. There are a whole bunch of different formulations of B complex so consult the label for dose and withdrawal information.

Vitamin B 12 is a prescription product that will stimulate appetite and is often used along with treatment for other disease. The most common formulation is 3000 mcg /ml but there are at least two other strengths so look at the label.  The usual dosage of the 3000 mcg/ml product is 1-2 ml per head SubQ  and there is no withdrawal.

Bo Se is a combination of Vitamin E and Selenium it is used to treat and prevent Vitamin E and Selenium deficiency.  This is common in some parts of the country and other parts of the country have adequate and even excess selenium in the soil. So you need to work with your local veterinarian. BoSe is a prescription product the dose is 1 cc per 40 pounds IM or SubQ  and withdrawal is 14 days.  

TrueGlo is an all natural feed supplement with probiotics, MOS, Beta Glucans, and Octacosanol. It is feed every day to support the immune system, healthy joints and the building of the right kind of muscle.

Over the Counter Antibiotics

Penicillin G works well against gram positive organisms that are not resistant.  It is usually used at an extra label dose so you need to work with your veterinarian. We label it at 5 c per hundred pounds IM for our clients and the new recommended withdrawal is 51 days when it is administered at that dose.  It must be administered every 24 hours and limit it to no more than 10 cc per injection site. With the new longer withdrawal we have all but eliminated using penicillin in pigs. 

Tylan 50 and 200 Both of these have the same antibiotic at different concentrations. They are labeled for swine pneumonia, erysipelas, arthritis, and scours. We probably use them most often to treat growing and finishing pigs with scours and occasionally for lame pigs. The dosage for Tylan 50 is 1 cc per 12.5 pounds and for Tylan 200 1 cc per 50 pounds IM. Do not inject more than 5 cc in an injection site. The withdrawal is 14 days.

LA 200 is oxytetracycline 200 mg / ml. It is used to treat pneumonia and occasionally scours. Some also give it to sows after farrowing to help control baby pig scours and prevent mastitis and metritis in the sow. It is usually given at 4.5 cc per 100 pounds which does not need to be repeated for 72 hours. It can also be administered at 1.5 or 2.5 cc per hundred pounds daily. Do not exceed 5 cc per injection site.

Lincomycin 100 or 300 These are the same medication in two different strengths. The most common reason we use this is for arthritis and Mycoplasma pneumonia. The dose is 1 cc per 20 pounds for Lincomycin 100 and 1 cc per 60 pounds for Lincomycin 300. Technically Lincomycin 300 is only supposed to be used in pigs over 300 pounds. So if you intend to use it in smaller pigs that is extra label use and you should consult your veterinarian. The withdrawal for both is 48 hours.

Prescription Antibiotics There are a number of prescription antibiotics that your veterinarian might recommend  I will just talk about three.

Draxxin  is labeled for swine respiratory disease and is active against the majority of bacterial agents that cause respiratory disease.  Draxxin is a “go to” medication for pigs with pneumonia. It is unique in it has a short withdrawal time but delivers several days of therapeutic levels of drug in the lung. The dosage is 0.25 cc / 22 pounds IM and the withdrawal is 5 days.  

Baytril is another good treatment for respiratory disease in pigs. Baytril is in a special class and there is no extra label use of this medication allowed. Baytril is another “go to” for respiratory disease. If you use it follow the label exactly so you stay within the law. The dosage is 3.4 cc/ 100 pounds SubQ and the withdrawal is 5 days.

Naxcel / Excenel RTU / Excede  All three of these are the same antibiotic in three different forms and with two different dosages and withdrawals.All three are prescription products. FDA has recently restricted the use of these products. They can not be used as blanket treatments to prevent disease and they must be used at the dose on the bottle. There is still some limited extra label use. For example you can still use Naxcel to treat a pig with Strep meningitis or inner ear infection if you follow the label dosage. 

Naxcel comes as a dry powder that you reconstitute with water.  Once you mix it te product is good for 7 days in the refrigerator. If you still have some left at the end of the 7 days you can freeze and keep it for 8 weeks but when you thaw it one time discard any unused portion.  The dosage is 1 cc per 22 to 37 pounds IM and repeat the dosage daily for three days. The withdrawal period is 4 days. 

Excenel RTU is essentially the same as Naxcel but in a ready to use shelf stable format that you store at room temperature.  You need to shake it well before use. The dose is the same as Naxcel 1 cc per 22 to 37 pounds IM three days in a row and the withdrawal is 4 days. 

Excede has a long duration of activity so it does not have to be re-administered. The dosage is 1 cc per 44 pounds and the withdrawal is 14 days.  Do not administer more than 2 cc per injection site.

Monday, October 22, 2012

October 2012

Many of you will get this in your email box in the next few days. Until then you can read it here.
 
Why we do what we do
Almost every week we get phone calls and notes from our customers. Our favorites are ones like the two that I have copied.  

One of our goals is to make products that not only help the best elite feeders get the most out of the pigs they are feeding but also help average and even novice feeders have a more enjoyable experience. 

These letters come from average families that have a show pig project. 

They also have dance recitals, ball games, track meets, and a hundred other things going on. These families don’t eat on a regular schedule and neither do their show pigs. With all the rides needed Mom’s taxi cannot run on a regular schedule that gets them to the pig barn at the same time every day. 

The teens that feed these pigs are incredibly adept at detecting subtle differences in the text messages their friends send but they might be a bit distracted when it comes to noticing subtle differences in their pig from day to day. 

We are talking about the effects of TrueGlo on muscle in this issue of our newsletter and that is important and the increased drive your pigs will make your show ring experience much better.

The features of TrueGlo that make pigs eat and keeps them eating are threefold. First, the flavoring agents we use have a very pleasant odor and it will bring pigs to the feeder to investigate as soon as you top-dress it. Then over the long haul the probiotics, yeast, and MOS in TrueGlo stimulate a healthy appetite and a healthy digestive system. It is because of that healthy digestive system that pigs stay on feed when the inevitable inconsistent feeding schedule happens.  Last the beta glucans in TrueGlo stimulate the immune system, which helps keep them on an even keel with fewer subtle day-to-day differences for teen feeders to notice or not notice. 

“Thank You,
My daughter used your product all season on her market hog,…
The judge said she brought her in absolutely perfect, there was nothing he would have done differently feeding, fit or nutrition wise, and congratulated my daughter on a "perfect "job.
That was the only pig he said that about at the show.
Our pigs looked healthy, fresh and vibrant.
Thanks to you and your product, we had a a very successful 4 H year .”

 
“Thank You As soon as we started top dressing the TrueGlo product both of our finicky eaters went right to the feeder and they never missed another feeding all year.
They both made weight and when you told me they would 3 months ago I thought you were out of your mind. Thanks again we never had as much fun feeding pigs as we did this year!”

Better experiences like these for great kids and families is why we do what we do. Give us a call we’d love to play a small role making your project more fun and successful.

Dave

If you have questions please call us at 888.603.2459
Or send me an email at dave@goinshowin.com

The Skinny on Muscle
Muscle! Muscle! Muscle!

Whether you show cattle, hogs, sheep or goats you want more muscle and you need the right kind of muscle to get into the champion drive.

This is how TrueGlo can help muscle work better and  get more of the right kind of muscle.

Warning Science Content!

I'm sorry in advance but to understand the issue we are going to have to get our geek on for a bit..

Skeletal muscle contains two general types of muscle fibers. Type 1 also called slow twitch muscle fiber are the fibers that are slow to fatigue and important if you are a long distance runner. Type 2 are called fast twitch they fatigue quickly and produce lactic acid and are important for sprinters.

In the early part of exercise the fast twitch muscles are the most active and as lactic acid starts to build up you feel the "burn" and the slow twitch fibers take over. 

If you do long durations of exercise consistently your muscles begin to favor the Type 1 slow twitch fibers. There is nothing wrong with that but it does not work well for show stock.

Think about it this way if the exercise program favors the Type 2 fast twitch muscles you or your livestock will have a look closer to an NFL running back.

If your exercise program favors the Type 1 slow twitch muscles the end result looks more like a marathon runner.

Obviously the look we are after in all species of show stock is a lot closer to the running back than the marathon runner.

So what does this have to do with TrueGlo?

The octacosanol in TrueGlo does two things to help you get the look and the performance you want. First, octacosanol improves the ability of the muscle to metabolize and get rid of the lactic acid. Lactic acid is what causes the "burn" you feel when you exercise and it is what feeds the Type 1 muscle fibers.

Getting rid of the lactic acid increases the amount of time your stock can exercise before activating the Type 1 fibers.

The second benefit is by improving the muscle fiber metabolic activity endurance is greatly increased. That means your lamb, goat, calf or hog is going to drive flat out longer than the competition.

Those are the reasons that octacosanol is one of a handful of performance supplements that are listed in the US Navy Seal Fitness Manual. The Navy Seals use it because it works and it will give you the competitive edge in the show ring.

TrueGlo provides the precise calibrated daily dose of octacosanol to get you in the champion drive.

Order Your TrueGlo Here or Ask your local feed supplier to carry TrueGlo.

Features and Benefits of TrueGlo
  •  Probiotics for Improved Digestive Health and Better Appetite
  •  Prebiotics for Improved Digestive Immunity
  •  β Glucan Polysaccharides for Improved General Immunity
  •  Octacosanol for Improved Muscle Development and Endurance
  •  Combination of Palatable ingredients for Improved Appetite
  •  All Natural So There is No Withdrawal

Congratulations!
Congratulations to True North customer Diamond V Show Pigs on their Champion Crossbred boar at the National Swine Registry Summer Type Conference in Louisville this summer.

If you have question please call us at 888.603.2459
Or send me an email at dave@goinshowin.com